Tablet Danzen DS (Serratiopeptidase)
5mg, 10mg
DESCRIPTION:
DANZEN® (Serratiopeptidase), is a proteolytic enzyme. DANZEN (Serratiopeptidase) has high enzyme activities including potent anti-inflammatory, anti-tumefacient, bradykinin decomposing, mucolytic and fibrinolytic actions.
COMPOSITION:
DANZEN® TABLETS
Each enteric coated tablet contains:
Serratiopeptidase 5 mg (10,000 Serratiopeptidase units)
DANZEN DS TABLETS
Each enteric coated tablet contains:
Serratiopeptidase 10 mg (20,000 Serratiopeptidase units)
(Product Specs: Helix Pharma)
PHARMACOLOGICAL ACTIONS:
Intense Fibrinolytic Action.
DANZEN® (Serratiopeptidase) Strongly lyzes fibrin and fibrinogen but does not appreciably affect proteins in the living body such as albumin and oc orð globulin.
Potent Bradykinin Decomposing Activity.
DANZEN® (Serratiopeptidase) alleviates pain by inhibiting the release of specific pain-inducing amines known as bradykinin.
Elimination of inflammatory edema:
DANZEN® (Serratiopeptidase) inhibits inflammatory edema by improving the aggravated circulation in the inflammatory focus through breakdown of abnormal
exudates and proteins thereby promoting the absorption of the decomposed products in the blood and lymph vessels.
Acceleration of Liquefaction and Elimination of Sputum, Pus and Hematoma.
DANZEN (Serratiopeptidase) accelerates the elimination of sputum, pus and hematoma by breaking down and liquefying mucous secretions and fibrin clots.
Enhancing Effect On The Transfer Of Antibiotics To The Focal Site.
DANZEN® (Serratiopeptidase) increases the concentration of antibiotics at the site of infection.
INDICATIONS:
DANZEN® (Serratiopeptidase) is indicated for the treatment of the following inflammatory conditions:
Surgery: Post-operative edema and hematoma, remission of swelling after surgical stitching, resolution of tissue drainage, ease in post anesthetic sputume xpectoration.
Otorhinolaryngology: Acute & chronic sinusitis, Otitis Media, Acute Tonsillitis, Laryngitis, Pharyngitis, Rhinopharyngitis, Inflammation of Eustachian tube, Post Nasal Drip, Nasal Obstruction.
Obstetrics and Gynecology: Mastopathy, Galactostasis, Adnexitis, Salpingitis, Lateral episiotomy, Perineal laceration.
Orthopedics: Rheumatoid and Osteoarthritis, Orthopedic Surgery, Bone Fracture, Tendonitis, Ecchymosis, Sprains.
Dentistry and Oral Surgery:
Inflammation of Gums, Periodontosis, Alveolar Abscess, Alveolar Fracture and Tooth Fracture after Exodontia, Surgery of the Buccal Area.
Pneumology:
Bronchitis, Bronchiectasis, Difficulty of expectoration in Bronchitis, Pulmonarytuberculosis and Bronchial Asthma, Inadequate expectoration of sputum after anesthesia.
DANZEN (Serratiopeptidase) Increases the penetration of antibiotic when given concomitantly.
DOSAGE AND ADMINISTRATION:
DANZEN ( Serratiopeptidase) Tablets, 5mg: Usually given for adults in a dose of 1-2 tablets orally, three times daily before or after each meal. Dose may be
increased depending on the severity of the disease or as prescribed by the physician.
DANZEN® (Serratiopeptidase) DS Tablets, 10mg: Usually given for adults in a dose of 1 tablet orally, three times daily before or after each meal. Dose may be
increased depending on the severity of the disease or as prescribed by the physician.
ADVERSE EFFECTS:
DANZEN® (Serratiopeptidase) is generally well tolerated. The range of adverse effects observed are as follows:
1. Hypersensitivity reactions such as redness or rashes, which may infrequently occur.
2. Gastrointestinal: Diarrhoea may occur, Anorexia, gastric discomfort, nausea or vomiting may occur infrequently.
Drug Interaction:
DANZEN® (Serratiopeptidase) may intensify the effect of anticoagulants when administered concomitantly, therefore DANZEN® (Serratiopeptidase) should be
given with caution to those patients who takes anticoagulants or having blood coagulation abnormalities.
PRECAUTIONS:
This product should be administered with caution to the following patients:
1. Patients with blood coagulation disorder.
2. Patients with serious hepatic or renal disorder.
TOXICITY:
Chronic Toxicity
DANZEN® (Serratiopeptidase) showed no chronic toxicity when given several times higher than usual human dose to rats when given for 6 months.
Acute Toxicity
DANZEN (Serratiopeptidase) has Ld50 over 2000 mg/kg which is several thousand times higher than usual dose.
Teratogenic effects
DANZEN (Serratiopeptidase) showed no teratogenic effect in experimental animals when given several times higher than usual human dose.
INSTRUCTIONS:
Protect from heat, light and moisture. Keep out of reach of children.
Store below 30°C
To be sold on prescription of registered medical practitioner only.
PRESENTATION: DANZEN® (Serratiopeptidase) 5mg is available in blister pack of 2 x 10 tablets with product insert.
DANZEN DS (Serratiopeptidase) 10mg is available in blister pack of 2 x 10 tablets with product insert.
For oral use only.
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